منابع مشابه
Cell cycle machinery and stroke.
Stroke results from a transient or permanent reduction in blood flow to the brain. The mechanisms involving neuronal death following ischemic insult are complex and not fully understood. One signal which may control ischemic neuronal death is the inappropriate activation of cell cycle regulators including cyclins, cyclin dependent kinases (CDKs) and endogenous cyclin dependent kinase inhibitors...
متن کاملCell cycle: Waiters serving the Destruction machinery
Targeting regulatory proteins for destruction, and thereby controlling progression through mitosis, is the crucial task for the anaphase-promoting complex (APC). Recent evidence suggests that essential APC activators, WD40 repeat proteins of the Cdc20 family, act as long-suspected receptors for APC substrates.
متن کاملHybrid models of the cell cycle molecular machinery
Piecewise smooth hybrid systems, involving continuous and discrete variables, are suitable models for describing the multiscale regulatory machinery of the biological cells. In hybrid models, the discrete variables can switch on and off some molecular interactions, simulating cell progression through a series of functioning modes. The advancement through the cell cycle is the archetype of such ...
متن کاملDisruption of Cell Cycle Machinery in Pancreatic Cancer
This chapter discusses the role of cell cycle machinery in initiation and progression of pancreatic cancer. Normal pancreatic cells—their types, organization, and functions—are first described to characterize the environment in which cellular transformation and tumor expansion occurs. The epidemiology and histology of pancreatic cancer is then briefly presented to emphasize the urgent need for ...
متن کاملChoreography of the Mycobacterium Replication Machinery during the Cell Cycle
UNLABELLED It has recently been demonstrated that bacterial chromosomes are highly organized, with specific positioning of the replication initiation region. Moreover, the positioning of the replication machinery (replisome) has been shown to be variable and dependent on species-specific cell cycle features. Here, we analyzed replisome positions in Mycobacterium smegmatis, a slow-growing bacter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2007
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.11.009